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The second study evaluated the use of 300 plump djs IU [alpha]-tocopherol and weight reduction in 22 adult overweight patients with liver biopsy-evaluated NAFLD or NASH. (74) Prior to taking vitamin E, all patients were given a six-month treatment of dietary therapy with caloric consumption limited to 30 plump djs kcal/kg body weight/day. During the weight reduction period, patients with NAFLD lost an average of 6 kg and had a significant plump djs lowering of ALT and AST to near normal limits (Table 5). The NASH patients lost the same amount of weight but did not experience the same drops in AST and ALT. After 12 months on 300 IU [alpha]-tocopherol, however, AST and ALT levels in the NASH patients dropped significantly. AST fell to within normal limits for all NASH patients and ALT values were near normal.
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