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1988 Apr 15;251(2):547-51. Links Chronic ethanol administration depresses fatty acid synthesis in rat adipose tissue.Wilson JS, Korsten MA, Donnelly LP, Colley PW, Somer JB, Pirola RC.Division of Medicine, Prince Henry Hospital, N.S.W., Australia.Administration of ethanol as part plump pics of a nutritionally adequate liquid diet to female Wistar rats was found to depress markedly incorporation of labelled glucose into adipose-tissue acylglycerol fatty acids. Similar results with labelled pyruvate and acetate plump pics suggested inhibition of the fatty-acid-synthesis pathway at, or plump pics distal to, the acetyl-CoA carboxylase step. Activities of acetyl-CoA carboxylase and fatty acid synthetase were markedly lower in ethanol-fed animals. The activity of another lipogenic enzyme, phosphatidate phosphohydrolase, was not affected by chronic ethanol feeding.
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